Figure 6.
Identification of transcriptional signature in human iPSC-derived neurons with idiopathic ASD. (A,B) The eigengene of narrow (A) and broad (B) down-regulated gene signatures significantly separated idiopathic ASD patient iPSC-derived neurons from controls in work of Marchetto et al. (2017). Linear regression for ASD: (A) P = 2.2 × 10−3, (B) P = 2.7 × 10−2. (C,D) Using data collected from postmortem brain tissue, the eigengene of narrow (A) and broad (B) down-regulated gene signatures significantly differentiated individuals diagnosed with ASD. Linear regression for ASD: (C) P = 1.5 × 10−3, (D) P = 2.2 × 10−3. Control indicates neurons derived from neurotypical human iPSCs. (Adj) Adjusted.
