Assembly of a pangenome for global cattle reveals missing sequences and novel structural variations, providing new insights into their diversity and evolutionary history

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Figure 7.
Figure 7.

Evolution and function analysis of the Bov-tA1 insertion/deletion in APPL2. (A) The phylogenic tree of Bov-tA1 in APPL2 in species within ruminants. (B) Pie plot of genotype frequencies for Bov-tA1 deletion in APPL2 in cattle according to the geographical distribution. (C) Bov-tA1 location and sequence analyses. (D) GO enrichment analysis of the motifs in Bov-tA1 sequences in APPL2. (E) Boxplot of APPL2 expression levels in skeletal muscle and liver using RNA sequencing data. A number of 15 samples were randomly selected for each population.

This Article

  1. Published in Advance August 17, 2022, doi: 10.1101/gr.276550.122 Genome Res. 32: 1585-1601

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