Figure 2.
Gene-specific degradation rates shape mRNA dynamics. (A–G) Pre-mRNA (top panels) and mRNA expression profiles (bottom panels) of seven representative genes with rapid pre-mRNA dynamics. Pre-mRNA and mRNA expression profiles (points) were obtained by quantification of RNA-seq reads mapping to gene introns and exons, respectively. Pre-mRNA expression profiles are overlaid with impulse model fits (lines) to aid visualization. mRNA expression profiles are overlaid with the transcription model fits (lines) used to obtain gene-specific mRNA half-lives, presented in H.
