Chromatin landscape of the LMO2 (11p13), TLX3 (5q35), and TAL1 (1p33) loci in healthy mature T cells and three cell lines derived from T cell hematological malignancies. Upper panels show selected ChIP-seq chromatin states (Supplemental Table S1) of LMO2 (A), TLX3 (B), and TAL1 (C) loci in BLUEPRINT healthy mature T cells. Each line of the lower panels represents peaks of individual histone marks, separately for each cell line. (*) Cell line contains chromosomal aberration involving the displayed region as follows: KOPT-K1, LMO2-TRA/TRD; DND-41, TLX3-BCL11B; and Jurkat, 12-bp insertion upstream of the TAL1 gene (for details, see Supplemental Table S3). (#) Missing data for histone mark H3K27me3 in the Jurkat cell line.
