Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers

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Figure 1.
Figure 1.

Genomic and epigenomic architecture of the IGH locus (14q32) in healthy and malignant human hematopoietic cells. Each panel represents collapsed cell type–specific signal of ChIP-seq chromatin states included in this study (Supplemental Table S1). AID motif clusters were detected as high enrichment of AID motifs (more than 200 of RGYW motifs per 2.5 kb). (HSCs) Hematopoietic stem cells, (GC) germinal center, (CLL) chronic lymphocytic leukemia, (MCL) mantle cell lymphoma, (DLBCL) diffuse large B cell lymphoma, (BL) Burkitt lymphoma, and (MM) multiple myeloma.

This Article

  1. Published in Advance December 21, 2021, doi: 10.1101/gr.276042.121 Genome Res. 32: 1343-1354

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