Exposome–metabolome interactions: metabolites and metabolic pathways that were significantly correlated with the exposome. (A) Spearman's correlation analysis between the exposome and metabolome. (B) Significantly correlated metabolic pathways revealed by pathway analysis using the KEGG database (|r| > 0.9; Q-value < 0.05). (C) Significant correlations between chemicals and top 20 biological exposome components and metabolites (represented by KEGG compound entry) and metabolic pathways revealed by Spearman's correlation networks (|r| > 0.9; Q-value < 0.05), with positive correlations shown in blue and negative correlations shown in red. The complete network is provided in Supplemental Figure S8.
