Exposome–proteome interactions: proteins and signaling pathways that were significantly correlated with the exposome. (A) Spearman's correlation analysis between the exposome and proteome (|r| > 0.9; Q-value < 0.05). Only the proteins with degrees > 5 are shown. The complete network is provided in Supplemental Figure S5. (B) Signaling pathways that significantly correlated with the exposome revealed by pathway analysis using KEGG, GO, and Reactome databases. Immune-related pathways are shown in bold. (C) Spearman's correlation networks between chemicals, top 20 biological exposome components, immune-related proteins, and signaling pathways (|r| > 0.9; Q-value < 0.05), with positive correlations shown in blue and negative correlations shown in red. A detailed network for each pathway is provided in Supplemental Figure S6.
