Snake venom gene expression is coordinated by novel regulatory architecture and the integration of multiple co-opted vertebrate pathways

Candidate transcription factors (TFs) underlying VG regulation. (A) Candidate TFs involved in venom regulation, with the first three columns representing three approaches for TF identification, and the last three columns indicating TF membership in functional categories. (B) Interactions between candidate TFs and ERK (homolog of human MAPK1) based on STRINGdb. TFs with direct interactions with ERK are shown in dark blue, and TFs that interact with these are shown in light blue. Node sizes are scaled by the number of interactions with other TFs in the network. TFs also involved in the unfolded protein response (UPR) are highlighted in red.