Antibody titer statistics. (A) The distribution of antibody titers at four time points. Titers at time point “−3” show the number of BRD-specific antibodies without any antigen stimulation. Titers at time point “0” represent immediate memory responses triggered by the vaccine. Titers at time points “+3” and “+6” reflect antibodies produced as a result of the vaccination. Details of the titer analysis are described in Kramer et al. (2017). (B) The matrix shows the Pearson's correlations between antibody titers at four time points. Correlation values vary from –1 (blue) to +1 (red). Statistically insignificant correlations (P ≥ 0.05) are shown as white cells. (C) Antibody titers at time point “+6” versus usages of IGHV1-7 at time point “+3.” (D) Antibody titers at time point “+6” versus fractions of ultralong CDR3s in all CDR3s at time point “+3.” The Pearson's correlations (r) and P-values (P) are shown at the top of panels C and D.
