MYC overexpression leads to increased chromatin interactions at super-enhancers and MYC binding sites

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Figure 4.
Figure 4.

Chromatin interactions are enriched at super-enhancers and gained chromatin loops tend to connect MYC binding sites. (A) Percentage of Hi-C chromatin loops occupied by MYC compared to randomly shuffled loop coordinates. Percentage of MYC-bound chromatin loops are shown as orange dots. Box plots show 1000 iterations of MYC occupancy at random genomic loci of the same size and on the same chromosome as the actual chromatin loops. (B) Percentage of chromatin loop anchors occupied by MYC. (C) Percentage of Hi-C chromatin loops connecting cis-regulatory elements. (D) Percentage of cis-regulatory elements with Hi-C chromatin loops.

This Article

  1. Published in Advance February 3, 2022, doi: 10.1101/gr.276313.121 Genome Res. 32: 629-642

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