Variant-disrupted gene regulation affecting network modularity is enriched for coronary-/heart-related functions in CMs for an individual with a CAD disruption signature. GO terms enriched in genes with high DM scores for individual 18, the individual with the highest TF disruption score for ERG. Several GO terms related to coronary/cardiac function are enriched in highly ranked DM genes in CMs but not in LCLs and iPSCs. Point size corresponds to the number of high-DM genes annotated with the corresponding GO term. For display purposes, several generic GO terms enriched only in CMs were omitted in this figure. The entire set of enriched GO terms can be seen in Supplemental Figure S18, as well as Supplemental Tables S9–S11.
