Characterization of DFREs detected in HPCs. (A) Fraction of HPC silencers working as DFREs. (B) Evolutionary sequence conservation measured using the overlap with the conserved segments (left) and common SNP density (right) of HPC DFREs, SLrs, and ENrs. The background in Figure 2 is also included here (represented by “background”) for consistency. (C) Enrichment of GWAS SNPs and eQTLs in the HPC. The number of SNPs per kilobase is listed in the bars. (B,C) The asterisks above the bars represent the significance levels compared with the background. (D) Developmental specificity of DFREs, SLrs, and enhancers in HPCs. The numbers in bars are the numbers of REs. (shared) REs shared in HPCs and T cells, (specific) REs acting in HPCs but not in T cells. (**) P < 10−5.
