Epigenetic traits are linked to validation in STARR-seq. (A) Venn diagram comparing the number of SNPs in an open chromatin region in HAECs (bottom), in an H3K27ac peak (right), or validated in STARR-seq (left). (B) Enrichment of SNPs in epigenetic trait peaks in the STARR-seq-validated SNP set. H3K27ac (top four) restricted to various sizes around the center of the peak. (C) Peak size density of ATAC-seq peaks and H3K27ac ChIP-seq peaks. (D) Enrichment of SNPs in ENCODE open regions that are shared and not shared with HAECs. (E) Venn Diagram comparing the number of SNPs that are molQTLs (right) and validated in STARR-seq (left). (F) Enrichment of molQTL SNPs in STARR-seq-validated SNPs. (G) Heat map of number of STARR-seq-validated SNPs in subsignificant molQTL bins.
