ARC-C defines significant interactions between regulatory elements, candidate regulators, and a role for BLMP-1 in mediating interactions. (A) Types of elements and types of interactions involved in the 14,901 significant interactions. (B) Interaction distances of the significant interactions, separated by element type. (C) Expression correlation between pairs of genes with linked promoters compared to randomly paired genes in the set. (Left) All pairs of linked genes (n = 5142); (middle) pairs for which both genes are in the bottom 30% of CV values (wide expression; n = 2224); (right) pairs for which both genes are in the top 70% of CV values (regulated expression; n = 879). (D, left) Contact frequency between binding sites of indicated proteins; (right) change in contact frequency in blmp-1 mutants compared to wild type (log2). Interactions among blmp-1 down targets are significantly reduced. See Methods for details and Supplemental Table S5 for data.
