Associations between aspects of mtDNA evolution in MA lines. (A) Associations for lines at the initial time point. The heatmap shows the odds ratio for each pair of binary variables among mtDNA deletion, mtDNA recombination, respiration, mtDNA instability, and aneuploidy instability. FDR-corrected P-values of Fisher's exact test: (*) P ≤ 0.05, (**) P ≤ 0.01, (***) P ≤ 0.001. (B) Counts of MA lines for each comparison with a statistically significant association, classified as true (T) or false (F) for the given variable. The shaded background comprises associations between mtDNA deletion and respiration that were not statistically significant. (C,D) Same as A and B, but for lines at the final time point.
