Figure 5.
FISH validation of a 17-Mbp inversion. NSI Strand-seq view of NLE Chromosome 22a and HSA Chromosome 2 shows the incomplete switch in the orientation of 17 Mbp against both reference genomes, suggesting the presence of a heterozygous inversion (Chr2_inv16). Metaphase FISH experiments in human, NSI, and NLE show that the region is inverted in heterozygous state only in NSI and is in direct orientation in both human and NLE. (HSA) Homo sapiens; (NSI) Nomascus siki; (NLE) Nomascus leucogenys.
