Spatial organization of chromosomes leads to heterogeneous chromatin motion and drives the liquid- or gel-like dynamical behavior of chromatin

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Figure 6.
Figure 6.

Anomalous behavior in uniform models. (A) Cartoon to depict “middle” and “border” monomers, along with the center of mass and the radius of gyration of a TAD. (B) Comparison between MSDs of the monomers in the middle (mid) and borders (bor) of TAD and of the center of mass of the TAD (com) (A) from uniform heteropolymer models with TAD length of 200 kbp (left), 400 kbp (middle), and 800 kbp (right) for two different intra-TAD strength of interaction (black: 0 kT/null model, blue: −0.05 kT, red: −0.1 kT). The spatial sizes Formula for the different strengths of interaction are shown as dotted lines. (C,D) Formula as a function of Formula and tmin as a function of the TAD length L for the uniform models and for different strengths of interaction.

This Article

  1. Genome Res. 32: 28-43

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