A full-proteome, interaction-specific characterization of mutational hotspots across human cancers

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

Association of cancer-type-specific hotspots with specific protein interactions. (A) Categorization of pan-cancer versus cancer-type-specific hotspots and multicancer versus single-cancer hotspots. (B) Degree distributions of proteins harboring multicancer and single-cancer hotspots. Degree values are transformed by log2 for presentation purposes. (C) Edge betweenness distributions of multicancer and single-cancer interactions. (D) Average number of cancer types shared between hotspots on the same interface and between hotspots on different interfaces.

This Article

  1. Published in Advance December 28, 2021, doi: 10.1101/gr.275437.121 Genome Res. 32: 135-149

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research