Application of ChIP-exo in human tissue using PCRP mAbs. ChIP-exo heatmap, composite, and DNA sequence four-color plots are shown for the indicated number and type of bound motifs for the indicated targets, in the indicated organ types (the liver includes two donors). The 5′ end of aligned sequence reads for each set of experiments was plotted against the distance from the cognate motif, present in the union of all called peaks between the data sets for each indicated target. Reads are strand-separated (blue, motif strand; red, opposite strand) and total-tag-normalized across samples. Rows are linked across samples and sorted based on their combined average in a 100-bp bin around each motif midpoint.
