Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases

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Figure 4.
Figure 4.

Genes that escape and variably escape XCI are enriched for heritability. (A) Distribution of heritability enrichment for all self-reported phenotypes available in females (240 phenotypes), males (218 phenotypes), or both (280 phenotypes). Heritability was independently assessed for each XCI state: escape (E), variably escape (VE), and silenced (S). X genes with Y homologs that escape or variably escape are differentiated (Y homolog). (B) Lupus heritability enrichment measured in females (392 cases, 182,316 controls).

This Article

  1. Published in Advance August 23, 2021, doi: 10.1101/gr.275677.121 Genome Res. 31: 1629-1637

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