Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans

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Figure 2.
Figure 2.

Mutation rates. (A–C) Type-specific base-substitution rates, by strain. (D–F) Size-specific indel rates, by strain. (A,D) Genome-wide mutation rates; (B,E) rates at nonmononucleotide repeat sequence; (C,F) mononucleotide repeat sequence. All rates are scaled as 10−9 per base per generation; note the difference in y-axis scale between panels A–C and panels D–F. Error bars, one SEM.

This Article

  1. Published in Advance August 17, 2021, doi: 10.1101/gr.275372.121 Genome Res. 31: 1602-1613

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