Figure 3.
miRNA expression in human oocytes and embryos. (A) Venn diagram of miRNA species (260 in total) that are shared or uniquely expressed in human oocytes (n = 12), zygotes (n = 5), and embryos (n = 10). (B) Heatmap of miRNAs with highest expression levels (top 35 according to median, observations in >80% of samples) across samples. (C) FDR and effect size of the 21 differentially expressed (DE; FDR < 0.05) miRNAs between oocytes and embryos according to MACAU 2.0 (Sun et al. 2017). (D) Heatmap of DE miRNA row Z-scores. (B,D) Euclidean distance and average linkage were used to cluster miRNAs by expression.
