Characterizing nucleotide variation and expansion dynamics in human-specific variable number tandem repeats

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 4.
Figure 4.

A VNTR in PCBP3 shows repeat motif differences in modern superpopulations. (A) PCBP3 repeat motifs with variable positions highlighted. At left is the assigned color code for each motif. At right is the relative abundance of each motif in the 1000 Genomes Project and in ancient genomes. (B) Composition plot of the PCBP3 VNTR in geographically diverse populations. At the left are listed the genomes from which the allele has been obtained, which were previously sequenced and published (Audano et al. 2019). Black segments in the plot denote motifs with private variants. (C) Cumulative frequency of repeat motifs in PCBP3 across superpopulations. Repeat motifs are ordered by decreasing abundance in the African superpopulation, and numbers on the y-axis correspond to their global ranked abundance.

This Article

  1. Genome Res. 31: 1313-1324

Preprint Server