Consequences of dsRNA-associated gene deletion on mouse phenotypes using GREAT (McLean et al. 2010). Only the Gene Ontology “Mouse Phenotype Single knockout” is shown. The list of the top 20 enriched terms of the other gene ontologies is given in Supplemental Table S4. (A) The parsed list of 1893 genes that form dsRNA was tested for enrichment against all protein-coding mouse genes (21,395). The mouse phenotype single KO database contains 9170 entries that cover 9466 or 44% of all genes. (B) Phenotypes enriched after knockout of dsRNA genes expressed in mouse liver on the background of all genes. (C) Phenotypes enriched after knockout of dsRNA genes expressed in mouse testis (1888 genes or 16%) on a background of genes that are expressed in testis (11,649).
