A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes

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Figure 6.
Figure 6.

A model of KMT2A-AFF1-driven FFL and cascade network motifs that interface with MYC, BCL2, and CASP9 genes. MYC and BCL2 are regulated through many different TFs along with KMT2A-AFF1. MYB and RUNX1 act in combination at these loci, where combined disruption appears to enhance MYC dysregulation. CASP9 is regulated in a cascade motif, with RUNX1 acting as an intermediate node, where disruption induces CASP9 up-regulation.

This Article

  1. Published in Advance June 4, 2021, doi: 10.1101/gr.268490.120 Genome Res. 31: 1159-1173

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