Deep sequencing of 1320 genes reveals the landscape of protein-truncating variants and their contribution to psoriasis in 19,973 Chinese individuals

PTVs with high population differentiation in allelic frequency between Chinese (CHN), non-Finnish European (NFE), and African (AFR) populations. (A) Target-wide Z(F_ST) Manhattan plot. Note that Weir and Cockerham F_ST was normalized and transformed into Z values and the Bonferroni correction set the significant Z(F_ST) cutoff at 4.3. (B) (Top) Gene structure of FUT2. (Bottom) Nucleotide sequence and allele frequency distribution of a stop-gained G-A PTV (rs601338) with a Z(F_ST) of 18.5. (C) (Top) Gene structure of EFCAB13 with five PTVs of significant Z(F_ST). (Bottom) Nucleotide sequence and allele frequency distribution of a splice-acceptor G-A PTV (rs76299620) with a Z(F_ST) of 12.2.