Figure 7.
The model for heterochromatin reorganization in senescent cells. During senescence, there are multiscale reorganizations of heterochromatin. B-to-A regions are associated with H3K27me3. Compared with H3K9me3-depleted regions, H3K9me3-associated heterochromatin of G tended to increase both long and local interactions and form novel loops. These changes were accompanied with loss of H3K9me3, gain of H3K27me3, and increased chromatin accessibility. Both B-to-A regions and increased-interaction TADs showed gene expression leakage.
