The loss of heterochromatin is associated with multiscale three-dimensional genome reorganization and aberrant transcription during cellular senescence

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Figure 6.
Figure 6.

Gene expression leakage and aberrant repetitive element expression. (A) Distribution of gene expression (FPKM) for all biological replicates. Sequencing depths are labeled on the right. The sequencing depths are similar across all replicates, ruling out the effects of different sequencing depths. (B) Distribution of gene expression for different compartment categories. Gene expression leakage is enriched in shared-B and B-to-A categories. (C) Distribution of gene expression for different TAD types. Gene expression leakage is enriched in increased-interaction TADs. (D) Differential repetitive element expression during senescence. The colors represent the class to which repeat elements belong.

This Article

  1. Genome Res. 31: 1121-1135

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