Tissue-specific reprogramming of host tRNA transcriptome by the microbiome

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Figure 5.
Figure 5.

Mutation heat maps of common methylation types within cytosolic or mitochondrial tRNAs according to the standard tRNA nomenclature. The modification level of each type of tRNA methylation was semiquantified based on the corresponding mutation fraction, and presented data are from four tissues (n = 3 for both GF and SPF mice). (A) N1-methyladenosine of position 58 (m1A58) within cytosolic tRNAs. (B) N1-methylguanosine of position 37 (m1G37) within cytosolic tRNAs. (C) N1-inosine of position 37 (m1I37) within cytosolic tRNAs. (D) N3-methylcytosine of position 32 (m3C32) within cytosolic tRNAs. (E) N3-methylcytosine of position 47 (m3C47) within cytosolic tRNAs. (F) N1-methyladenosine or N1-methylguanosine of position 9 (m1A/G9) within mitochondrial tRNAs.

This Article

  1. Published in Advance April 15, 2021, doi: 10.1101/gr.272153.120 Genome Res. 31: 947-957

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