Distinct roles for RSC and SWI/SNF chromatin remodelers in genomic excision repair

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Figure 7.
Figure 7.

Working model of role of RSC in NER. Our data suggest RSC plays a role in both subpathways of NER. (A) In GG-NER, we propose RSC is recruited to UV damage through Rad4 and is subsequently tasked with remodeling nucleosomes in order to increase accessibility to TFIIH and/or other downstream NER proteins. (B) In TC-NER, RSC may be recruited to remodel nucleosomes to induce RNA Pol II backtracking, or may directly act on RNA Pol II and aid in its eviction from the CPD lesion to promote subsequent repair.

This Article

  1. Published in Advance May 17, 2021, doi: 10.1101/gr.274373.120 Genome Res. 31: 1047-1059

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