Linking the dynamics of chromatin occupancy and transcription with predictive models

Cadmium induces genome-wide chromatin dynamics that correlate well with genome-wide transcriptional dynamics. (A) Heat maps of changes in chromatin occupancy measures and transcription rate for all genes and all times, relative to 0 min (left: promoter small fragment occupancy; middle: gene body nucleosome disorganization; right: transcription rate). Genes (rows) are sorted by combined chromatin score. (B) Detailed heat maps of the 20 genes whose combined chromatin scores increase (top) or decrease (bottom) most. (C) Scatterplot of relationship between change in small fragment occupancy and log₂ fold-change in transcription rate, each averaged over the time course. (D) Scatterplot of relationship between change in nucleosome disorganization and log₂ fold-change in transcription rate, each averaged over the full time course.