Evolution of protein-coding genes expressed in different cell types. (A–C) Funnel plots summarizing the evolution of protein-coding genes specifically expressed in different cell types within the human cerebral cortex (Supplemental Table S6; Nowakowski et al. 2017) (A), human cortical layers (Supplemental Table S6; Hodge et al. 2019; Tasic et al. 2018) (B), and the mouse cerebellum (Supplemental Table S6; Carter et al. 2018) (C). (D) Venn diagram of the PSGs expressed specifically in those cell types, with the corresponding Protein–Protein Interaction network (STRINGdb) (Jensen et al. 2009) and their annotated association with micro- and macrocephaly (HPO) (Köhler et al. 2019). (EN-V1) primary visual cortex neurons; (RG-early) radial glia early cortical progenitors; (MGE-div) medial ganglionic eminence dividing cells; (Exc) excitatory; (L3-5) layers 3–5; THEMIS, UBE2F, PLA2G7, and so forth are cell type markers.
