Systematic detection of brain protein-coding genes under positive selection during primate evolution and their roles in cognition

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Figure 3.
Figure 3.

Brain protein-coding genes and human diseases. (A) Distribution of ωGC12 and Venn diagrams describing SCGs and PSGs situated at the extremes of the ωGC12 distribution (>2SD) specifically expressed in the brain (genes with specificity Z-score > 2 in any brain-related tissues of Figs. 1D and 2A), related to the synapse or brain diseases (Supplemental Table S4). (*) Addition of four genes (FARSB, KRT14, NPHS1, RSPH1) containing Homo sapiens–specific mutations predicted as deleterious (CADD>15). (B) Odds ratios for protein-coding gene sets related to brain diseases (Fisher's exact test; asterisks indicate P-values significant after Bonferroni correction; horizontal lines indicate 95% confidence intervals).

This Article

  1. Published in Advance January 13, 2021, doi: 10.1101/gr.262113.120 Genome Res. 31: 484-496

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