Modeling molecular development of breast cancer in canine mammary tumors

Dog PEP signature is predictive of survival in human breast cancer. (A,B) Kaplan-Meier plots showing patients with breast cancers bearing strongest Carcinoma PEP signal have worse outcomes in two independent human breast cancer cohorts: (A) TCGA BRCA; (B) METABRIC. (C–E) Dogs, like humans, have strong hormone receptor expression signaling differences between PAM50 subtypes. Estrogen receptor 1 (ESR1), progesterone receptor (PGR), and erb-b2 receptor tyrosine kinase 2 (ERBB2) expression within each PAM50 subtype shown: (C) TCGA BRCA; (D) this CMT data; and (E) METABRIC. Horizontal lines across each graph indicate median receptor expression across the entire cohort.