Contamination detection in sequencing studies using the mitochondrial phylogeny

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Figure 2.
Figure 2.

Violin plot representing the mean coverage over all 2504 samples in the two The 1000 Genomes Project Consortium data sets (high-coverage and low-Coverage). Because of different tissues in the low-coverage data, different clusters of coverage can be observed, resulting in wrong mtDNA contamination estimates for nDNA. It can be seen that the second peak within the low-coverage group vanishes for the high-coverage data, resulting in better estimates for extrapolation.

This Article

  1. Published in Advance January 15, 2021, doi: 10.1101/gr.256545.119 Genome Res. 31: 309-316

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