Post-transcriptional circadian regulation in macrophages organizes temporally distinct immunometabolic states

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Figure 2.
Figure 2.

Comparison of circadian transcripts and proteins reveals a significant role for post-transcriptional and post-translational regulation. (A) The percentage of total oscillating transcripts (blue) or proteins (orange) peaking at a given time was plotted on a radial histogram by circadian time of peak, binned in 1-h windows. (B) A heat map comparing the difference in the peak phases of corresponding oscillating transcripts (blue) and proteins (orange) binned into 2-h intervals over circadian time for genes circadian at both the mRNA and protein level. (C) Density graph displaying the lag time to protein creation from the peak time of corresponding oscillating transcript levels for genes circadian at both the mRNA and protein level.

This Article

  1. Genome Res. 31: 171-185

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