Intergenic ORFs as elementary structural modules of de novo gene birth and protein evolution

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Figure 3.
Figure 3.

From ancIGORFs to de novo genes. Plot of the HCA score of each ancIGORF (black and white points for single and multiple ancIGORFs, respectively) along with its corresponding de novo gene (blue points). Each de novo gene is connected to its parent ancIGORF(s) with a colored line. A de novo gene is connected to several IGORFs when it results from the combination of different ancIGORFs (i.e., multiple-ancIGORF de novo genes). Green lines indicate cases in which a de novo gene is connected to a low HCA score ancIGORF, and gray and pink lines indicate connections with an intermediate and a high HCA score ancIGORFs, respectively. The HCA score densities of de novo genes and ancIGORFs are shown in gray (bottom and top of the graph, respectively).

This Article

  1. Genome Res. 31: 2303-2315

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