Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits

Integration of cell type–specific open chromatin regions with UK Biobank GWAS reveals cell type roles in complex phenotypes. UK Biobank LDSC-partitioned heritability results for traits for which at least one cell type showed significant heritability enrichment after Benjamini–Yekutieli correction (LDSC coefficient P < 0.05) across all cell types and traits. Asterisks denote the significant cell type–trait combinations. One trait name has been shortened to preserve space: “Diseases of veins, lymphatic vessels, and lymph nodes, not elsewhere classified” has been shortened to “Diseases of veins, lymphatic vessels, and lymph nodes.”