Structural variants are a major source of gene expression differences in humans and often affect multiple nearby genes

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Figure 3.
Figure 3.

Mechanistic insights into outlier-associated SVs. (A) Enrichment of outlier-associated SVs in functional genomic annotations compared with control-associated SVs. Asterisks indicate statistical significance based on a Fisher's exact test with Bonferroni correction for multiple testing. (B,C) The distribution of the number of noncoding primary (B) and secondary (C) outliers found within 1 Mb of the region surrounding tissue-restricted outlier-associated SVs, control-associated SVs, and a shuffled null.

This Article

  1. Published in Advance September 20, 2021, doi: 10.1101/gr.275488.121 Genome Res. 31: 2249-2257

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