Figure 5.
Mechanisms for how Alu insertion polymorphisms associated with breast cancer affect gene expression levels. For each of four loci (A–D), a series of ectopic reporter constructs were tested: the Alu in the genomic locus (+Alu); the locus with no Alu present (−Alu); the isolated locus-specific Alu sequence (Alu); and the genomic locus with a scrambled Alu sequence (Scr). (*adjusted P < 0.05, t-test). Error bars are the standard deviation of two clones tested in triplicate in two experiments (n = 12).
