A multi-enhancer RET regulatory code is disrupted in Hirschsprung disease

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Figure 3.
Figure 3.

TF-mediated in vitro and in vivo effects on gene expression. (A) siRNA-mediated knockdown of PAX3, SOX10, GATA2, RARB, and RET in SK-N-SH cells decreases RET gene expression significantly. (B) siRNA-mediated knockdown of PAX3 has significant transcriptional effects on SOX10 but small yet statistically insignificant decreases on GATA2 and RARB. (**) P < 0.001 in three technical replicates for five independent biological replicates in all experiments.

This Article

  1. Published in Advance November 15, 2021, doi: 10.1101/gr.275667.121 Genome Res. 31: 2199-2208

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