A multi-enhancer RET regulatory code is disrupted in Hirschsprung disease

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Figure 2.
Figure 2.

Identification of cognate TFs bound to RET enhancers. Genome map of the RET locus with locations of the E2 and E27 CREs together with ChIP-qPCR results using a PAX3 antibody in SK-N-SH cells shows enrichment of binding compared with the background. The specificity of binding is shown by siRNA knockdown of PAX3 with concomitant reduction in ChIP-qPCR signals at both CREs. (**) P < 0.001 for two technical replicates for three independent biological replicates (n = 6).

This Article

  1. Published in Advance November 15, 2021, doi: 10.1101/gr.275667.121 Genome Res. 31: 2199-2208

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