Bivalent promoters with poised RNA polymerase II are enriched for MAPK1 (also known as ERK2) but not TFIIH. ChIP-seq read density profiles of histone modifications H3K4me3 and H3K27me3 (Marks et al. 2012), phosphorylated forms (S2p, S5p, or S7p) of RNA polymerase II (RNAPII) (Brookes et al. 2012), general transcription factor TFIIH (ERCC3) (Tee et al. 2014), and mitogen-activated protein kinase MAPK1 (Tee et al. 2014) near transcription start site (TSS) of indicated gene classes in mouse ESCs grown in serum-containing medium. Mean ChIP-seq signal is shown. Confidence interval (95%) of the mean is shown as a cloud. (RPM) reads per million mapped reads. See also Supplemental Figure S6.
