Figure 4.
Projecting mouse tumor immune cells onto the human reference atlas. (A,B) UMAP single-cell transcriptome representations of mouse T cells isolated from tumor organoids. Cells are color-coded by their predicted cell type based on the human reference atlas (A) or by cluster identity (B). (C) Cell type composition of each cluster (color code as in A). (D) Marker gene correspondence (Jaccard index) between the mouse immune clusters and the cell type clusters of the reference atlas. (E,F) UMAP representation of mouse T cells isolated from tumor organoids colored by predicted cell type (E, color code as in A) and clonality based on expanded TCR clonotypes (F).
