Figure 5.
RNA-Sieve results with confidence intervals in pseudobulk experiments. Inferred cell type proportions in pseudobulk experiments using data from the Tabula Muris Senis experiment for within-protocol (Smart-seq2 for both reference and pseudobulk) (A) and across-protocol (Smart-seq2 reference and 10x Chromium pseudobulk) (B) experiments. The black error bars on inferred proportions show the marginal 95% confidence intervals computed from the estimated Godambe information produced by RNA-Sieve. See “Confidence intervals” for mathematical details. Supplemental Table S2 contains the cell types in each organ, which could not be displayed because of space constraints.
