Likelihood-based deconvolution of bulk gene expression data using single-cell references

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Figure 4.
Figure 4.

Deconvolution results for real bulks from the Tabula Muris Senis. Roughly 40 real bulk samples across 10 ages were deconvolved using RNA-Sieve in each of the limb muscle (A), bone marrow (B), and spleen (C). In all cases, Smart-seq2 data were used as the reference. Each point represents the inferred proportion for a given cell type in a bulk sample. Lines display the smoothed trend of proportions as a function of age, with uncertainty shown by the shaded intervals.

This Article

  1. Published in Advance July 22, 2021, doi: 10.1101/gr.272344.120 Genome Res. 31: 1794-1806

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