Figure 1.
Sample selection strategy for population-based single-cell studies. (A) Genetic risk variant–enriched design in which individuals with the genetic risk variant are oversampled in order to achieve enough number of individuals that carry the genetic risk variant. (B) Extreme phenotype sampling design in which individuals with extremely low or extremely high phenotypes are selected. These extreme phenotype individuals are expected to carry more rare genetic risk variants than are individuals with intermediate phenotypes.
