Figure 1.
A gene module framework to characterize cancer cell states. (A) Gene modules emerge from the underlying gene regulatory network. Nodes and edges represent genes and coexpression, respectively. Colors indicate distinct gene modules. (B) Coherent gene modules interact with other modules to define a malignant cell's state. (C) The spectrum of states available to a cell can be described as a state potential map, where some states are shared across patients, cancer types, cell types, or clones for example, whereas others are accessible only in particular contexts.
