Figure 6.
HT-induced indels are disproportionally located in nucleosome-free DNA. Nucleosome profiling of indel and SNV mutations in ST-grown (Ossowski et al. 2010; Jiang et al. 2014) and HT-grown MA lines. (Predicted) Random expectation nucleosomal-associated versus nonnucleosomal distributions, as based on the distributions of MNase-seq bases (Supplemental Table S4A,B); (Observed) actual distribution of indels and SNVs in ST (Ossowski et al. 2010; Jiang et al. 2014) and HT conditions Supplemental Table S5A–D).
