LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy

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Figure 2.
Figure 2.

Evaluation of the developmental state of SMA somatic motor neuron somas. (A) PCA with development-related genes (DGs, 1341 genes) of all somatic motor neurons in control and SMA. (B) Plot of PC1 alone to better visualize the “age component.” (C) Venn diagram depicting overlap between DGs and all differentially expressed genes between control and SMA (DEGs, no fold-change cutoff, Padj < 0.05) per cell type and time point.

This Article

  1. Published in Advance August 20, 2020, doi: 10.1101/gr.265017.120 Genome Res. 30: 1083-1096

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